CONDITION OF EPIDERMAL FIBRILS IN EPITHELIOMA. 299 
Fig. a 1. — Enlarged drawing of three prickles at the junction of two 
cells, with the fibrils traversing them ; abnormal effect due to insufficient 
fixation. 
Fig. 2. — A prickle-cell, in which the fibrils are massed together in 
distinct bundles, the fibrils being much thicker than in a healthy cell. 
The fibrillar degeneration is more advanced than in fig. 1 d. Note the 
increase in volume of cytoplasm, dn. Remains of cells from which 
fibrils have been withdrawn. 8 oc. and 2 mm. immersion. 
Fig. 3. — A yet later stage of degeneration is exhibited in the cell to 
the left. The fibrils are being withdrawn from the periphery of the 
cell, and collected in a dense sheath round the nucleus. The two cells to 
the right have lost nearly all their fibrils and their cytoplasm is 
diminished. 2 oc. and 2 mm. immersion. 
Fig. 4. — Final stage in the degeneration of the prickle cell of an 
epithelioma. Here the fibrils are confined entirely to the neighbourhood 
of the atrophied nucleus, and have melted together to form a mantle 
completely surrounding the same. The nucleus has lost its chromatin 
and linin network, and only a few indistinct granules remain. 8 oc. and 
2 mm. immersion. 
Fig. 5. — An “epithelial pearl” or cell nest, composed of a number 
of cells arranged concentrically. The cytoplasma of the different cells 
have coalesced for the greater part into one mass. /. and li. Degenerating 
nuclei in which the nucleoli have fragmented, and with the chromatin 
network diffused, h. Final stage of the combination of two or more 
cells as in fig. 6. 2 oc. and 2 mm. immersion. 
Fig. 6. — A body composed of two cells, with fibrils arranged in two 
rings, in. Internal, en. external nucleus. 2 oc. and 2 mm. immersion. 
Fig. 7. — Diagram sketch of another concentric double ring, similar 
to fig. 6, but composed of three cells, I, internal cell, II and III, 
external cells. 
VOL. 57, PART 3. NEW SERIES. 
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