66 
D. D. CUNNINGHAM. 
water : — '' The larva is very feeble and tends to turn over on its 
back when at rest. The thin portions of the tail to the naked 
Tig. 5.— AmOBboid cells* A & B x 1000, C X 180. A. Healthy cell. 
B. Portion of a starved cell. C. Starved cells* 
eye appear of a whitish colour in place of presenting the trans- 
parent aspect normal to them> and when examined with a simple 
lens are found to be covered with innumerable white points. 
Under higher powers these points are resolved into granule cells in 
various stages of development. Large numbers of fully-matured 
granule cells are everywhere present, and the number of partially 
developed ones is very great. Some of the latter are merely begin- 
ning to be distinguished from the surrounding epidermal cells by 
their shining yellowish appearance, while others present various 
degrees of granular accumulation. The tissue of the deep 
layer of epidermis appears, as it were, opened out, the consti- 
tuent cells not being in such close contact with one another as 
they normally are. Empty granule-cell spaces abound, and here 
and there large areas occur in which the deeper epidermal tissue' 
is either entirely absent, or replaced by loose reticular tissue con- 
sisting of nuclear elements connected together by slender pro- 
cesses {^ide fig. 6). 
'' Granule cells sometimes occur, as it were, suspended in the 
midst of such reticular areas. The outer layer of epidermis 
appears little affected. There is no opening out of its texture, 
no hiatuses occur in it, the cells are everywhere closely in contact 
with one another, and the only abnormal appearances are pre- 
sented by the nuclei, which in many cases are broken up into a 
collection of large shining granules. The branched sub-epider- 
mal cells are greatly altered. They have lost their normal soft 
dim refraction and have become very conspicuous, appearing to 
