178 
H. M. WOODCOCK. 
thefiguresof Miucliiti ami Woodcock, loc. c i t .) and again in 
II alter! din in noctiun (c f. below), the cytoplasm of an 
infected corpuscle is usually stained deeply, like that of an 
uninfected one, even where, as in the former case, there is a 
certain amount of hypertrophy; in these, the parasite appears 
as a clear space, almost vacuole-like, surrounded by the dark 
cytoplasm. In Karyolysns the appearance is quite 
different. Figs. 20-22, 24-26 represent early stages in an 
infection as early as, or slightly later, than that of fig. 2, from 
a Giemsa smear. The nucleus of the corpuscle is either oval 
or beginning to elongate. In such cases the cytoplasm can 
still be made out, but it never appears any darker than is 
indicated in Figs. 20, 22, 24. The nucleus also retains the 
stain much less intensely than in an uninfected cell stained by 
the same method (cf. fig. 23), the actual masses and grains of 
chromatin standing out sharply from the finely granular or 
reticular ground substance. The host-cell nucleus, it will be 
seen, is at once displaced by the parasite, and pushed to one 
of the longer sides of the corpuscle. 
From being oval or slightly extended, the host-cell nucleus 
gradually becomes considerably elongated and greatlj’- 
narrowed, i. e. compressed (figs. 32-40) ; all stages in this 
transition can be found, the real change in shape being best 
realised, of course, in preparations stained by iron-luema- 
toxylin. In most cases the corpuscle-nucleus, in its final 
condition, appears like a slightly crescentic band, which is 
closely apposed to the parasite (or rather to its envelope) and 
follows its contour, curving round somewhat at either or both 
ends; this portion of the cell-nucleus is generally a little 
broader, i.e. less compressed than the rest, giving the whole 
nucleus the appearance of a bent club or halter, as the case 
may be.^ In all these instances the axis of extension of the 
host-cell nucleus is approximately parallel to the length of 
the parasite. Now and again, however, where the corpuscle- 
' The resemblance between this hypertropliied nnclexis and that of 
the spindle-shaped host-cell infected by Leucocytozoon is often 
striking (cf. figs. 11, 12, 18 and 19, PI. lU). 
