CHANGES IN CHONDlilOSOMES. 
555 
investigated in respect of three pathological cell states, namely : 
(1) in that obtaining in the cells of the liver when pig- 
mentaiy degeneration has occurred ; (2) in that obtaining in 
the convolnted tubules of the kidney during severe haenioglo- 
binminia ; and (3) in the epidermis when a marked degree of 
epithelial proliferation has been set up. In all these cases 
examination of chondriosomes is readily effected, special 
methods of chondriosomal fixation not being’ required, and 
Fig. 1. 
[The scale of figs. 1, 2, 5 and 6 is given below fig. 1 ; that of figs. 3, 4, 7, 
8, 9 and 10, below figs. 3 and 4.] 
0^ ' fOO/u ' 
Section of liver of healthy rabbit. The liver-cells are closely 
apposed, the usual ai-rangement in cell columns being 
oliscured. The blood-capillaries are indicated by red blood-cells 
darkly stained. The cytoplasm of the liver-cells exhibits 
numerous chondriosomes, appearing as deeply stained granules 
which obscure or conceal the nuclei. Fixed in Flemming’s solu- 
tion. Stained by Heidenliain's iron-alum hsematoxylin method 
X 200. 
thus the uncertainty and difficulty of chondriosomal staining 
is avoided. In the case of the liver and kidney it will be 
necessary, before studying the chondriosomes in the patho- 
logical state under consideration, to describe the normal 
appearance presented by the latter structures. It may be 
observed that in the liver and kidney, as in other secreting 
glands, the chondriosomes retain the embryonic type of 
VOL. 58, PAUT 3. — NEW SERIES. 37 
