CHANGES IN CHONDRIOSOMES. 
557 
by figs. 3 and 4)^ ai'e apparently related to the functional or 
nutritive condition of the cell.^ 
The appearance of the pigment-granules (unstained) in the 
liver-cells in pigmentary degeneration (figs. 2 and 4) is^ apart 
from their coloration, indistinguishable from that of the 
mitochondria (shown in fig. 3). Tlie granules are spherical or 
oval in shape, and are scattered irregularly throughout the 
cytoplasm. Those shown in fig. 4 are 0'3 ju to0‘6/x in length, 
but smaller (0‘2 p) and larger (0'8 fj) forms are also met with. 
The number of chondriosomes pi*esent in a single cell is 
Figs. 3 (to left) and 4 (to right). 
«- 1 1 1 1 
0/* >M/ul 
Fig. 3. — Liver-cell from fig. 1, more highly magnified. The 
c-hoiidriosomes, which are ahmulant, assume the form of well- 
defined, deeply stained granules, more or less ovoid in shape, 
ranging from U ft to2 U /u in diameter and arranged in groups. 
Fixed in Flemming's solution. Stained hy Heidenliain’s iron- 
alum hajuiatoxylin method. X lOtlO. 
Fig. 4. — Liver-cell from fig. 2, more highly magnified. The 
cytoplasm is denser than in the cell shown in fig. 3 and exhiliits 
a meshwork arrangement; it contains hlack (unstained) pig- 
ment-granules, which in appearance and size closely resemhle 
the chondriosomes shown in the preceding figure, Imt are 
fewer in numher. Fixed in Zimker's solution. Stained hy 
Heidenhain’s iron-alum haunatoxylin method. X 1000. 
‘ The rabbit from which figs. 2 and 4 were made was somewhat thin 
but seemed otherwise normal ; its liver-cells were small in size, thecyto- 
l)lasni being dense and presenting a finely vacuolated structure. The 
rabbitfroni which figs. 1 and 3 were made was exceedingly well nourished ; 
its liver-cells were large, the cytoplasm being abundant. 
37 § 
