CHANGES IN CHONDRIOSOMES. 
561 
figured by Yorke,^ the cells of the convoluted tubules in such 
conditions are filled with granules which may be of unusuully 
large size and are recognisable under a low magnification 
(fig. 8). Rod-like forms may also bo preseut^ but owing to 
their small size are not well seen. The granules which are 
situated towards the lumen of the tubules are well defined, 
more or less rounded in aspect, and reach as much as 2 ju to 
2'5 /i in diameter, granules of this size being fairly numerous, 
while in exception-il cases a diameter of 6 /i may be reached ; 
the smaller gTanules measure O'o /i to 0 8 ju across, the smallest 
granules being, however, 0'2 jn or less in diameter. These 
granules are irregularly scattered and exhibit no definite 
Figs. 9 (to left) and 10 (to right). 
Fig. 9. — Type of normal cell of convoluted tuljule prior to excretory 
activity. Tlie chondriosomes consist of cliondriokonts, lying 
near the hasenient memhrane, and mitochondria, arising from 
tlie cliondriokonts, and forming an outer granular layer reach- 
ing to the striated border of the cell, x 1000. 
Fig. 10. — Type of cell of convoluted tubule in severe hamio- 
globinmmia. The condition of the cell is indicative of extreme 
secretory activity. The cliondriokonts are much finer than in 
the preceding figure, while the mitochondria and secretory 
granules are numerous and of unusually large size, x lOOO. 
grouping. 'i'hu rod-like forms shown in fig. 8 ai'c slender 
and are situated more deeply than the granules, one end 
being attached to the basement membrane; their thickness 
usually ranges from 0'3 to 0'4 g, their length being about 
3 fi. The number of rods and granules observed in the cells 
of the convuluted tubules appeared to be approximately the 
same as in normal cells. In some cells no cliondriokonts 
could be seen, only mitochondria being observed. The smallest 
' Yorke, W., “ The Passage of Hmmoglobiu through the Kidneys,” 
‘ Annals of Tropical Medicine and Parasitology,’ 1911, vol. 5, p. 401. 
