562 
J. 0. WAKELIN BAERATT. 
granules are in tlie unstained condition colourless ; the larger 
granules are brownish, tlie depth of colour being proportional 
to their size. The coloui-ed granules stain less deeply with 
ha^inatoxylin than the smallest granules. 
The granules and rods just described are obviously chon- 
driosoines, some of which are larger than in the normal 
condition. The identity of the forms seen in hminoglobi- 
ueemia with chondriosomes is here more strikingly exhibited 
than is the case in the instance furnished by the pigmented 
liver of tlie rabbit, for we are dealing with two types, namely, 
rod-like forms and granules, and in both the normal and 
pathological condition the passage of rod-like forms into 
granules can be observed. For convenience of comparison 
of healthy and abnormal renal chondriosomes, a semi- 
diagrammatic representation of the two types is afforded by 
figs. 9 and 10. 
Regaud ^ has shown that in Ophidia and Amphibia the 
secretory granules of the kidney, which are discharged into 
the lumen of the convoluted tubule, arise in relation with the 
mitochondria, and these in turn are formed from chondrio- 
konts. 'I'his author figures the chondriokonts and secretory 
granules in the different stages of secretory activity of the 
renal cells, pointing out that the former are least numerous 
when the hitter are most abundant and vice versa. The 
cell shown in fig. 8 and represented diagrammatically in 
fig. 10 resembles an exaggerated degree of the condition 
figured by Regaud as that immediately preceding excretion, 
but it is not improbable that the functions of the cell repre- 
sented in fig. 8 have in reality become disordered to such an 
extent as to imperil the integrity of the cell. The brownish 
colour of the larger granules during haemoglobinaemia indi- 
cates the part taken by these structures in the elimination of 
hmmoglobiu. 
The significance of the pigmentary change exhibited by the 
cells of the liver is difficult to estimate, the relation of the 
chroudriosomes to the secretory activity of these cells being 
‘ Regaud. — Loc. cit. 
