Sir Everard Home on the 
with a dram of water, and conveyed into the circulation of a 
moderately sized dog by the jugular vein. The dog’s pulse 
in a natural state is 140 in a minute. 
In 5 minutes, the dog had a tremulous motion of the mus- 
cles and fluttering of the pulse, accompanied with nausea, but 
no retching to vomit. In 14 minutes, the pulse was 180 in a 
minute and had frequent intermissions. In 4 hours, the pulse 
was 120 in a minute, of its natural strength, and had fre- 
quent intermissions. In 7 hours, the dog had a natural 
motion, the pulse had no intermission, was 140 in the minute. 
The dog had a good appetite for food, and appeared in per- 
fect health. 
The same dog at the end of three complete days, swallowed 
60 drops of the same infusion, exactly double the quantity 
that had been introduced into the circulation. In 2 hours, he 
became languid, the pulse wiry and weak, but 140 in the 
minute. In 4-! hours, the languor much less and the pulse 
natural. In 8 hours, the dog had had a natural motion. In 
11 hours, was in good spirits and very well. 
The sensible effects, upon the dog, were similar to those 
produced upon myself, but in a less degree. Under the in- 
fluence of a violent fit of the gout, in the ankle, on the 23d of 
December, 1815, at 10 o’clock in the morning, I took 60 
drops of the eau medicinale ; the pain of the gout was insuf- 
ferable, I got into bed, and was so chilly as not to be able to 
keep my hands warm, even under the bed clothes. In 2 hours, 
I became rather hot and thirsty. In 3 hours, the pain was so 
much diminished as to be tolerable, while the limb was at rest. 
In 7 hours, I had a confined motion from the bowels, and the 
pain in the ankle became severe, while the foot was placed 
