Sir Everard Home's Appendix , &c. 2% 
It has been suggested to me since the Paper was read, that 
the only mode of proving that the medicine acts through the 
medium of the circulation, is to show that when a sufficient 
quantity is received into the blood, all the violent effects are 
produced, that result from a large dose taken by the mouth ; 
and as I had no object but the pursuit of truth, I lost no 
time in complying with this suggestion, and introduced into 
the circulation of a dog 160 drops of the same infusion before 
employed. 
The animal instantly lost all power of voluntary motion, 
the breathing became extremely slow, and the pulse was 
hardly to be felt. In 10 minutes, the pulse was 84, the inspi- 
rations natural, which are 40 in a minute. In 20 minutes, the 
pulse was 60, the inspirations 30 in a minute, a tremulous 
motion had taken place in the hind legs. In an hour, the 
pulse was 1 15, and irregular ; the animal was capable of sit- 
ting up, but was in a state of violent tremor, and the inspira- 
tions could not be counted. 
In hour, the tremor had gone off, the^ pulse continued 
the same ; the animal made ineffectual attempts to vomit, and 
continued to do so for ten minutes, accompanied with great 
languor; the inspirations were 34 in a minute. 
In 2 hours, the pulse was 130, and very weak; the animal 
had voided i|- ounce of water, had vomited twice, each time 
bringing up a quantity of mucus tinged with bile, and had 
two liquid stools. 
In 3 hours, had vomited again, and had another stool; the 
pulse too weak to be counted. 
In 4 hours, continued extremely languid. 
In 3 hours, vomited some bloody mucus, and expired. 
