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1. Levels of Physical Containment 67 
2. The Recommendation that All Permissible 
Recombinant DNA Experiments Be Conducted 
in National Facilities 69 
3. Experiments Prohibited at this Time 70 
D. No Guidelines but NIH Consideration of Each Proposed 
Project on an Individual Basis Before Funding 83 
E. General Federal Regulation of All Such Research. ... 83 
VII. Environmental Impact of the Guidelines 89 
A. Impact of Issuance of NIH Guidelines 89 
1. Impact on the Safety of Laboratory Personnel 
and on the Spread of Possibly Hazardous Agents 
by Infected Laboratory Personnel 90 
2. Impact on the Environmental Spread 
of Possibly Hazardous Agents 96 
3. Cost Impact 97 
4. Secondary Impacts 98 
B. Impact of Experiments Conducted Under the 
Guidelines 99 
1. Possible Undesirable Impacts 99 
2. Beneficial Impacts of Recombinant DNA 
Research 109 
VIII. Responses to Comments on the Draft Environmental 
Impact Statement . . 113 
viii 
