to 24 hr after the TIL infusion. IL-2 will be given for up to five 
consecutive days as tolerated. Under no circumstances will more than 15 doses 
of IL-2 be administered. The same toxicity criteria will be used as in our 
previous protocol (86-C-183c). Doses may be skipped depending on patient 
tolerance. Doses will be skipped if patients reach grade III or grade IV 
toxicity as detailed in Table 9. If this toxicity is easily reversed by 
supportive measures then additional doses may be given. 
8. Concomitant therapy; Patients may receive concomitant medications 
to control the side effects of therapy (4,5). It is our plan to administer 
the same concomitant medications used in all previous TIL protocols. These 
include: acetaminophen (650 mg every 4 hours), indomethacin (50-75 mg every 
six hours) and ranitidine (150 mg every 12 hours) throughout the course of 
treatment. Patients may receive intravenous meperidine (25-50 mg) to 
control chills when they occur, although chills are unusual after the first 
one to two doses of IL-2. Hydroxyzine hydrochloride (25 mg every six hours) 
is given to treat pruritis. Steroids will not be used in these patients 
and if steroid are required, then the patient will immediately be taken 
off protocol therapy. 
Recombinant DNA Research, Volume 15 
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