V. 
PATIENT EVALUATION 
Parameters to be measured 
Pre 
Physical exam 
History 
Performance Status 
Assess for Tumor Effect 1 
Chemistry Survey 2 
Vital Signs 
Weight 
CBC, Diff/ Platelet 
PT, PTT 
FEV1 , ABGs 
EKG 
CXR 
Cardiac Stress Test 
U/A and Culture 
Hb,Ag, HTLV III 
Brain CT or MRI 
Assess for adverse 
events status 
PCR on PBL to detect 
NeoR gene 
Tumor biopsy (if feasible) 
Western blot 
(4070A envelope) 
Serum assay for TNF 
During Therapy Week 
Study Dl.p3.p5.D6 D15 D17 D19 D20 7 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
X 
‘To include assessment of all sites of disease. 
includes total bilirubin, SGOT, LDH, Alkaline Phosphatase, Creatinine, Bun, 
CPK 
[76] 
Recombinant DNA Research, Volume 15 
