Recombinant DNA Advisory Committee - 10/7-8/91 
do not need to come to this committee anymore because there have been no problems 
to date treating a certain number of patients. 
Dr. Miller agreed with Dr. Anderson that the dual review is regressive, superfluous, and 
slow. Given that the RAC has little review other than gene therapy protocols, it seems 
self evident that the committee should reconstitute itself to be primarily concerned with 
gene therapy. 
Dr. B. Murray said that she did not see the need for two committees considering what 
has been done recently. The review of the protocols could be facilitated if the 
committees were merged. Dr. Mclvor did not agree that the process by which protocols 
moved through the system would speed up. There has not been a protocol that would 
have gone through the system requiring only one review. But what is absolutely 
apparent from the proceedings at this meeting is that there is a lot of repetitiveness. 
This argues strongly in favor of a single review. He reiterated a suggestion made by Dr. 
Epps that a working group could informally discuss some of the issues with the 
investigator; and make a series of provisions, if necessary. The protocol could be given 
conditional approval and then sent to the RAC for formal review. 
Dr. McGarrity said his understanding is that the subcommittee is looking at the future 
activities of the RAC. A motion could be passed to ask the HGTS to examine it's future 
relationship with the full committee. 
Dr. Schaechter proposed that the Chair call the question. 
Dr. McGarrity called a vote to call the question on Mr. Capron's motion. The motion to 
call the question passed by a vote of 8 in favor, 3 opposed, and 2 abstentions. 
Ms. Wilson stated that Mr. Capron's motion had been changed in item number one 
where the phrase "gene transfer experiments" was changed to "protocols involving human 
subjects " the second time it appears. In item number three, "during the coming year, 
pending taken actions" has been changed to "pending having taken action on" the 
recommendation. In current number three, where it begins "and as an interim matter," it 
would become item number four. 
Dr. Geiduschek said there was also a change in item number two where it says "The 
RAC establish a working group." That would change to "The RAC assigned to Dr. R. 
Murray's working group." 
Dr. McGarrity put the motion with the wording as amended to a vote. The motion 
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Recombinant DNA Research, Volume 15 
