MEDICAL RECORD 
STUDY NUMBER: 
CONTINUATION: ptflt-i-Of. 
in your windpipe (trachea) to allow mechanical breathing (breathing assisted 
by a machine). This would require transfer to the Surgical Intensive Care 
Unit. Less serious shortness of breath is common, and you may require oxygen 
delivered by a face mask during some portion of this treatment. Other side 
effects include fever and chills, which generally can be eliminated by 
appropriate medication. You also might develop nausea, diarrhea, a skin 
reaction with itching, nasal congestion, and abnormalities in kidney and liver 
function. Mental changes ranging from confusion and forgetfulness to 
disorientation have occasionally been observed. Other possible side effects 
include fatigue and mouth dryness. Your blood counts may drop to the point 
where you need red blood cell or platelet transfusions. Heart problems can 
occur, including irregular heart beat, low blood pressure, and heart attack. 
Some patients have developed a hole in their colon, resulting in abdominal 
inflammation and infection that required correction by surgery. In previous 
st udies many of these side effects such as the weight gain, nausea, diarr hea 
and liver and kidney dysfunction disappeared or were alleviated after sto pping 
the IL-2 administration. Other unknown side effects may occur. It is very 
unlikely, though possible, that this treatment could kill you. 
Immune lymphocytes 
The administration of the lymphocytes may cause fever, chills, and 
shortness of breath. Based on our previous experience, these side effects are 
expected and should only last a few hours. Because these lymphocytes are 
grown from your tumor, it is possible that the lymphocytes returned to you may 
contain tumor cells. T 
PATENT IOC ♦fnP CATION 
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Recombinant DNA Research, Volume 15 
