14. Ruscetti, F.W., Morgan, D.A. and Gallo, R.C.: Functional and morpho- 
logic characterization of human T cells continuously grown in vitro. 
J. Immunol. 119:131-138, 1977. 
15. Taniguchi, T., Matsui, H. , Fujita, T., Takaoka, C. , Yoshimoto, R. and 
Hamuro, J.: Structure and expression of a cloned cDNA for human inter- 
leukin-2. Nature 302:305-307, 1983. 
16. Rosenberg, S.A., Grimm, E.A., McGrofan, M. , Doyle, M. , Kawasaki, E., 
Koths, K. and Mark, D.F.: Biological activity of recombinant human 
interleukin-2 produced in Escherichia coli. Science 223:1412-1415, 
1984. 
17. Smith, K.A. : The interleukin-2 receptor. Adv. in Immunol. 42:165-179, 
1988. 
18. Tanaka, T., Saiki, O., Soi, S., Negoro, S. and Kishimoto, S.: Inter- 
leukin-2 functions through novel interleukin-2 binding molecules in T 
cells. J. Immunol. 140:470-473, 1988. 
19. Smith, K.A. and Cantrell, D.A.: Interleukin-2 regulates its own 
receptors. Proc. Natl. Acad. Sci, USA 82:864-868, 1985. 
20. Fearon, E.R., Pardoll, D.M., Itaya, T., Golumbek, P., Levitsky, H.I., 
Simons, J.W. , Karasuyama, H. , Vogelstein, B. and Frost, P.: Interleukin- 
2 production by tumor cells bypasses T helper function in the generation 
of an antitumor response. Cell. 60:397-403, 1990. 
21. Gansbacher, , B., Zier, K. , Daniels, B., Cronin, K. , Bannerji, R. and 
Gilboa, E.: Interleukin-2 gene transfer into tumor cells abrogates 
tumorigenicity and induces protective immunity. J. Exr>. Med, 172: 
1217-1224, 1990. 
22. Hoover, H.C., Jr., Surdyke, M.G., Dangel, R.B., Peters, L.C. and Hanna, 
M.G. Jr. : Prospectively randomized trial of adjuvant active-specific 
immunotherapy for human colorectal cancer. Cancer 55:1236-1243, 1985. 
[140] 
Recombinant DNA Research, Volume 15 
