PATIENT EVALUATION TO DETERMINE 
ELIGIBILITY FOR GENE THERAPY 
FH Homozygote with 
Symptomatic CAD 
Receptor Status? 
Negative 
Defective 
Cardiac Eval 
-History and physical 
-Echo with Doppler 
Contraindications No Contraindications 
ot Eligible Additional Cardiac Eval: 
ETT +/- Angiogram 
Cardiac Eval 
-History and physical 
-Echo with Doppler 
Contraindications No Contraindications 
Not Eligible 
Previous CABG? 
CANDIDATE 
Yes No 
Additional Cardiac Eval: Angiogram 
ETT +/- Angiogram 
CANDIDATE 
Minor Disease 
Not Eligible 
Severe 
Disease 
Consider 
for CABG 
CANDIDATE 
Recombinant DNA Research, Volume 15 
[173] 
