TABLE OF CONTENTS 
I. Call to Order and Opening Remarks 5 
II. Minutes of October 7-8, 1991, Meeting 5 
III. Comments of Dr. Gerard McGarrity 5 
IV. Proposed Amendment to Appendix D-XV of the NIH Guidelines 
Regarding a Human Gene Therapy Protocol Entitled: Treatment 
of Severe Combined Immunodeficiency Disease (SCID) Due to 
Adenosine Deaminase (ADA) Deficiency with Autologous Lymphocytes 
Transduced with a Human ADA Gene /Dr. Anderson 5 
V. Proposed Addition to Appendix D of the NIH Guidelines 
Regarding a Human Gene Therapy Protocol Entitled: Gene 
Transfer for the Treatment of Cancer /Dr. Freeman 24 
VI. Proposed Addition to Appendix D of the NIH Guidelines 
Regarding a Human Gene Therapy Protocol Entitled: 
Immunotherapy of Malignancy by In Vivo Gene Transfer 
into Tumors /Dr. Nabel 31 
VII. Future Role of the Human Gene Therapy Subcommittee/Amend 
Points to Consider/ Amend NIH Guidelines Sections III-A 
and IV-C 37 
Vni. Proposed Amendment to Appendices B-I-B-l and B-I-B-2 of 
the NIH Guidelines Regarding the Bacterial Order 
Actinomycetales 41 
IX. Amendment to Appendices B-I-C-l and B-I-B-l in the NIH 
Guidelines Regarding Mycobacterium avium 42 
X. Proposed Addition to Appendix D of the NIH Guidelines 
Regarding a Human Gene Therapy Protocol Entitled: 
A Phase I /II Study of Cellular Adoptive Immunotherapy 
Using Genetically Modified CD8+ HIV-Specific T-Cells 
for HIV-Seropositive Patients Undergoing Allogeneic 
Bone Marrow Transplant /Dr. Greenberg 43 
XI. Amendment to ADA Protocol (Continued from Day 1) 51 
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Recombinant DNA Research, Volume 15 
