XI. Cardiac toxicity in autoimmunity. 
In addition to the studies reported in the paper by Stewart 
et al. (see Appendix) , several additional pieces of data have 
been included. The data presented in the paper by Stewart et al. 
documents that there are no changes in CPK enzymes prior to, 16 
hours post or 3 -days post-injection with DNA liposome complexes 
and there are no pathologic autoimmune changes in the heart or 
other organs. In addition, no evidence of ischema or toxicity 
was observed by electrocardiographic analysis. Representative 
examples of the electrocardiographic tracings from these mice are 
included on the following pages to document these studies. In 
addition, a total of 8 rabbits received intravenous injection 
with DNA liposomes containing the PLJ H-2K S plasmid. Total CPK 
and CPK MB enzyme was assayed. There was no detectable CPK MB 
present before or after injection, and no significant increases 
in CPK (Table I) . These data are summarized below (Appendix) . 
Recombinant DNA Research, Volume 15 
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