Cancer Clinical Trials 
COMMON 
TOXICITY CRITERIA 
Grade 
TOXICITY 
0 
1 
2 
3 
4 
WBC 
> 4.0 
3-4,000 
1,000-2,999 
300-999 
< 300 
PLT 
WNL 
75 .0-normal 
50.0-74.9 
25.0-49.9 
< 25.0 
Hgb 
WNL 
10 .0-normal 
8.0-10.0 
6. 5-7. 9 
< 6.5 
Infection 
none 
mild 
moderate 
severe 
life- 
threaten- 
Nausea 
none 
able to eat 
intake 
no 
_ _ 
reasonable 
significant- 
significant 
intake 
ly decreased 
but can eat 
intake 
Vomiting 
none 
1 episode in 
2-5 episodes 
6-10 
> 10 
24 hrs. 
in 24 hrs. 
episodes in 
episodes 
24 hrs. 
in 24 hrs. 
or 
requiring 
parenteral 
support 
Diarrhea 
none 
increase of 
increase of 
increase of 
increase 
2-3 stools/ 
4-5 stools/ 
7-9 stools/ 
of > 10 
day over 
day, or 
day, or 
stools/day 
pre-Rx 
nocturnal 
incontinence 
or grossly 
stools, or 
or severe 
bloody 
moderate 
cramping 
diarrhea, 
cramping 
or need 
for 
parenteral 
support 
Stomatitis 
none 
painless 
ulcers , 
erythema, or 
mild 
soreness 
painful 
erythema, 
edema , or 
ulcers , but 
can eat 
painful 
erythema , 
edema, or 
ulcers , and 
cannot eat 
requires 
parenteral 
or enteral 
support 
Bilirubin 
WNL 
< 1.4 x N 
1. 5-3.0 
x N 
3. 1-5.0 
> 5 x N 
Transaminase 
( SG0T , SGPT) 
WNL 
< 2.5 x N 
2. 5-5.0 
x N 
5.1-20.0 x N 
> 20.0 x N 
Aik Phos . 
or 5' 
nucleotidase 
WNL 
< 2.5 x N 
2. 6-5.0 
x N 
5.1-20.0 x N 
> 20.0 x N 
Recombinant DNA Research, Volume 15 
[449] 
