COMMON TOXICITY CRITERIA (continued) 
i 
Grade 
TOXICITY 
0 
1 
2 
3 
r 
4 
Liver - 
clinical 
no change 
from 
baseline 
- ” 
precoma 
hepatic 
coma 
f 
Creatinine 
WNL 
< 1 . 5 x N 
1. 5-4.0 x N 
4. 1-7.0 x N 
> 7.0 x N 
Proteinuria 
no change 
1+ or < 0.3 
g% or < 3 
g/1 
2-3+ or 0.3- 
1.0 g% or 3- 
10 g/L 
4+ or > 1.0 
g% or > 10 
g/L 
nephrotic 
syndrome 
Hematuria 
neg 
micro only 
gross, no 
clots 
gross + 
clots 
requires 
trans fu- 
sion 
Alopecia 
no loss 
mild hair 
loss 
pronounced 
or total 
hair loss 
| 
f 
Pulmonary 
none or 
no change 
asympto- 
matic, with 
abnormality 
in PFT's 
dyspnea on 
significant 
exertion 
dyspnea at 
normal level 
of activity 
II 
dyspnea at 
rest 
; 
I 
i 
Cardiac - 
dysrhythmias 
none 
asympto- 
matic , 
transient , 
requiring no 
therapy 
recurrent or 
persistent, 
no therapy 
required 
requires 
treatment 
1 
requires 
monitoring 
or 
hypotens- 
ion, or 
ventri- 
cular 
tachycar- 
dia, or 
fibrilla- 
tion 
Cardiac 
function 
none 
asymptoma- 
tic, decline 
of resting 
ejection 
fraction by 
less than 
20% of 
baseline 
value 
asymptomatic 
decline of 
resting 
ejection 
fraction by 
more than 
20% of 
baseline 
value 
mild CHF, 
responsive 
to therapy 
1 
severe or 
refractory 
CHF 
!' 
| 
r 
if 
Cardiac- 
ischemia 
none 
non-specific 
T-wave 
flattening 
asymptoma- 
tic, ST and 
T wave 
changes 
suggesting 
ischemia 
angina 
without 
evidence for 
infarction 
acute 
myocardial 
infarction 
1 
i* 
ji 
[450] 
Recombinant DNA Research, 
Volume 15 
i 
L 
