COMMON TOXICITY CRITERIA (continued) 
Grade 
TOXICITY 
0 
1 
2 
3 
4 
Cardiac - 
pericardial 
none 
asymptomatic 
effusion, no 
intervention 
required 
pericarditis 
(rub, chest 
pain, ECG 
changes) 
symptomatic 
effusion; 
drainage 
required 
tamponade ; 
drainage 
urgently 
required 
Hypertension 
none or 
no change 
asymptoma- 
tic, 
transient 
increase by 
> 20 mm Hg 
(D) or to > 
150/100 if 
previously 
WNL. No 
treatment 
required. 
recurrent or 
persistent 
increase by 
> 20 mm Hg 
(D) or to > 
150/100 if 
previously 
WNL. No 
treatment 
required. 
requires 
therapy 
hyperten- 
sive 
crisis 
Hypotension 
none or 
no change 
changes 
requiring no 
therapy 
(including 
transient 
orthostatic 
hypotension) 
requires 
fluid 
replacement 
or other 
therapy but 
not hospi- 
talization 
requires 
therapy and 
hospitaliza- 
tion; 
resolves 
within 48 
hrs. of 
stopping the 
agent 
requires 
therapy 
and 
hospital- 
ization 
for > 48 
hrs. after 
stopping 
the agent 
Neuro- 
sensory 
none or 
no change 
mild 
paresthe- 
sias, loss 
of deep 
tendon 
reflexes 
mild or 
moderate 
obj ective 
sensory 
loss ; 
moderate 
paresthesias 
severe 
objective 
sensory loss 
or paresthe- 
sias that 
interfere 
with 
function 
Neuro-motor 
none or 
no change 
subjective 
weakness; no 
objective 
findings 
mild 
obj ective 
weakness 
without 
significant 
impairment 
of function 
objective 
weakness 
with 
impairment 
of function 
paralysis 
Neuro- 
cortical 
none 
mild 
somnolence 
or agitation 
moderate 
somnolence 
or agitation 
severe 
somnolence , 
agitation, 
confusion, 
disorienta- 
tion, or 
hallucina- 
tions 
coma, 
seizures , 
toxic 
psychosis 
Recombinant DNA Research, Volume 15 
[451] 
