COMMON TOXICITY CRITERIA (continued) 
Grade 
— t 
! 
i 
TOXICITY 
0 
1 
2 
3 
4 
% 
Neuro- 
cerebellar 
none 
slight 
incoordina- 
tion, 
dysdiado- 
kinesis 
intention 
tremor , 
dysmetria, 
slurred 
speech, 
nystagmus 
locomotor 
ataxia 
cerebellar 
necrosis 
t 
1 
Neuro-mood 
no change 
mild anxiety 
or 
depression 
moderate 
anxiety or 
depression 
severe 
anxiety or 
depression 
suicidal 
ideation 
Neuro- 
headache 
none 
mild 
moderate or 
severe but 
transient 
unrelenting 
and severe 
l 
Neuro- 
constipation 
none or 
no change 
mild 
moderate 
severe 
ileus > 96 
hrs . 
\ 
Neuro- 
hearing 
none or 
no change 
asymptomat- 
ic, hearing 
loss on 
audiometry 
only 
tinnitus 
hearing loss 
interfering 
with 
function but 
correctable 
with hearing 
aid 
deafness 
not 
correct- 
able 
f 
Neuro-vision 
none or 
no change 
symptomatic 
subtotal 
loss of 
vision 
blindness 
j 
Skin 
none or 
no change 
Erythema 
Dry, 
desquamation 
vesicula- 
tion, 
pruritis 
Moist, 
desquamation 
ulceration, 
pruritis 
requiring 
medication 
Exfolia- 
tive 
dermatitis 
necrosis 
requiring 
surgical 
interven- 
tion 
} 
l 
s 
1! 
[ 
jr 
Allergy 
none 
transient 
rash , drug 
fever < 38C, 
100. 4F 
urticaria, 
drug fever - 
38C , 100. 4F 
mild 
bronchospasm 
serum 
sickness , 
broncho- 
spasm, req. 
parenteral 
meds . 
anaphylax- 
is 
f 
P 
1 
i 
] 
[452] 
Recombinant DNA Research, 
Volume 15 
) 
1, 
I 1 
I 
f 
1 
