COMMON TOXICITY CRITERIA (continued) 
Grade 
TOXICITY 
0 
1 
2 
3 
4 
Fever in 
absence of 
infection 
none 
37. 1-38. 0C 
98. 7-100. 4F 
38. 1-40. 0C 
100. 5-104. OF 
> 40. 0C, 
> 104. OF for 
< 24 hrs . 
> 40. 0C 
(104. OF) 
for more 
than 24 
hrs . or 
fever 
accompa- 
nied by 
hypoten- 
sion 
Local 
none 
pain 
pain and 
swelling, 
with 
inflammation 
or phlebitis 
ulceration 
plastic 
surgery 
indicated 
Weight 
gain/loss 
< 5.0% 
5. 0-9. 9% 
10.0-19.9% 
> 20.0% 
-- 
Hypergly- 
cemia 
< 116 
116-160 
161-250 
251-500 
> 500 or 
keto- 
acidosis 
Hypoglycemia 
> 64 
55-64 
40-54 
30-39 
< 30 
Amylase 
WNL 
< 1 . 5 x N 
1. 5-2.0 x N 
2. 1-5.0 x N 
> 5 . 1 x N 
Hypercal- 
cemia 
<10.6 
10.6-11.5 
11.6-12.5 
12.6-13.5 
>13.5 
Hypocalcemia 
> 8.4 
8. 4-7. 8 
7. 7-7.0 
6. 9-6.1 
< 6.0 
Hypomag- 
nesemia 
> 1.4 
1.4-1. 2 
1.1-0. 9 
0.8-0. 6 
< 0.5 
Fibrinogen 
WNL 
0.99-0.75 
x N 
0.74-0.50 
x N 
0.49-0.25 
x N 
< 0.24 x N 
Prothrombin 
time 
WNL 
1.01-1.25 
x N 
1.26-1.50 
x N 
1.51-2.00 
x N 
> 2.00 x N 
Partial 
thrombo - 
plastin time 
WNL 
1.01-1.66 
x N 
1.67-2.33 
x N 
2.34-3.00 
x N 
> 3.00 x N 
Recombinant DNA Research, Volume 15 
[453] 
