17.0 Non-technical Abstract 
Many types of cancer cannot be cured by traditional medical 
treatments, including drugs, surgery, or radiation. In this 
study, an experimental treatment will be offered that may help to 
fight this disease. We will attempt to induce tumor regression 
by the introduction of genetic material that directs the 
symthesis of a protein which stimulates the immune system. The 
genetic material, DNA, will be introduced directly into the tumor 
by mixing it with fat bodies, or liposomes, and this mixture will 
be injected into the tumor. The DNA will be taken into cells and 
cause them to produce a protein that stimulates tissue rejection. 
This protein, called HLA-B7 , causes cells which contain it to be 
recognized as foreign by the immune system. The goal of the 
treatment is to stimulate the immune system to attack and kill 
the tumor. In this study, we will determine a safe and effective 
dose to administer the DNA/liposome complex. Increasing amounts 
of this complex will be used in different patient populations. 
If no side effects are observed, repeated treatments will be 
instituted. The expression and nature of the immune response 
will also be characterized. This treatment may provide a 
therapeutic effect in cancer and could be applied to the 
treatment of other diseases. 
Recombinant DNA Research, Volume 15 
[461] 
