TITLE OF PROTOCOL: 
1/5/92(31) 
THE TREATMENT OF PATIENTS WITH METASTATIC MELANOMA AND RENAL CELL 
CANCER USING IN VITRO EXPANDED AND GENETICALLY-ENGINEERED 
(NEOMYCIN PHOSPHOTRANSFERASE) BULK, CD8(+) AND/OR CD4(+) TUMOR 
INFILTRATING LYMPHOCYTES AND BULK, CD8(+) AND/OR CD4(+) PERIPHERAL 
BLOOD LEUKOCYTES IN COMBINATION WITH RECOMBINANT INTERLEUKIN-2 
ALONE, OR WITH RECOMBINANT INTERLEUKIN-2 AND RECOMBINANT ALPHA 
INTERFERON 
ABBREVIATED TITLE: GENE TRANSFER INTO TIL SUBPOPULATIONS 
INVESTIGATORS: 
James S. Economou, M.D.,Ph.D. 
Assoc. Professor of Surgery 
Division of Surgical Oncology 
UCLA School of Medicine 
54-140 CHS 
Los Angeles, CA 90024 
(310) 825-2644 
Robert A. Figlin, M.D. 
Assoc. Professor of Medicine 
Division of Hematology /Oncology 
Department of Medicine 
UCLA School of Medicine 
Los Angeles, CA 90024 
(310) 825-5788 
Edwin Jacobs, M.D. 
Asst. Professor of Medicine 
Div. of Hematology /Oncology 
UCLA School of Medicine 
Los Angles, CA 90024 
Sidney Golub, Ph.D. 
Professor of Microbiology 
Immunology, and Surgery 
Division of Surgical Oncology 
UCLA School of Medicine 
Los Angeles, CA 90024 
Jean DeKemion, M.D. 
Professor and Chief 
Division of Urology 
UCLA School of Medicine 
Los Angeles, CA 90024 
Robert C. Moen, M.D.,Ph.D. 
Genetic Therapy, Inc. 
19 Firstfield Road 
Gaithersburg, MD 20878 
[512] 
Arie Belldegrun, M.D. 
Assoc. Professor of Surgery 
Division of Urology/Surgery 
UCLA School of Medicine 
66-138 CHS 
Los Angeles, CA 90024 
(310) 206-1434 
E. Carmack Holmes, M.D. 
Professor of Surgery 
Division of Surgical Oncology 
UCLA School of Medicine 
54-140 CHS 
Los Angeles, CA 90024 
(310) 206-1028 
Donald Kohn, M.D. 
Asst. Prof. Pediatrics and 
and Microbiology 
Dept, of Research 
Immunology /Bone 
Marrow Transplantation 
USC School of Medicine 
4650 Sunset Blvd. Box 62 
Los Angeles, CA 90027 
Hungyi Shau, Ph.D. 
Asst. Prof, of Surgery 
Div. Surgical Oncology 
UCLA School of Medicine 
Factor Bldg. 9-267 
Los Angeles, CA 90024 
(310) 206-6095 
William H. McBride, Ph.D., Sc.D. 
Dept, of Radiation Oncology 
UCLA School of Medicine 
Los Angeles, CA 90024 
Recombinant DNA Research, Volume 15 
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