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BIOGRAPHICAL SKETCH ~ 
G^e :~e ‘o-ow-g n'-^ation ‘or the Key personnel consultants, anc :o 'accra'ors stec r rage 4 
Photocooy this cage ‘or each ge'son 
NAME 
James S. Economou, M.D.,Ph.D. 
POSITION T i T lE 
Associate Professor 
of Surgery 
BlRT-DA'E V; ■■ 
lf-7-51 
EDUCa^ C N Begin .vtn baccaiau'eate c ether ritiai pro'essic^ai education, s^cn as -1'5,-ig arc -g 
INSTITUTION AND LOCATION 
DEGREE 
YEAP 
CCNFE 3Q ED 
The Johns Hopkins University 
B.A. 
1972 
The Johns Hopkins University, 
M.D. 
1980 
School of Medicine 
Ph.D. 
L. 
a 
= E_D 2= 
Biology 
Medicine 
Immunology 
RESEARCH AND'OR PROFESSIONAL EXPERIENCE Concluding with present position, ist m cnronoiogiC3i o r der p'ev g_s e~: ; . -- • 
penence. and honors. Include present memoershio on any Federal Government Public Advisory Committee List, m c^'c-z zz : - - 
titles and complete references to all oubiications during the past three years and to representative earner publications ce" - 
plication, 00 NOT EXCEED TWO PAGES 
1980-1986 Residency in General Surgery 
1986-1990 Assistant Professor of Surgery 
1990-pre Associate Professor of Surgery 
UCLA, UCSF 
UCLA 
UCLA 
Economou, J.S., Essner, R., Rhoades, K., McBride, W.H., Golub, S., Holmes, E.C., 
Morton, D.L. Molecular mechanisms of interleukin-2 ( I L- 2 ) induction of human 
necrosis factor (TNF) gene expression in macrophages. Surgical Forum 3f): 426-428, 
1988. 
Economou, J.S., Colquohoun, S.D., Anderson, T.M., McBride, W.H., Golub, 
S., Holmes, E.C., Morton, D.L. Interleukin-1 and tumor necrosis factor production 
by tumor-associated mononuclear leukocytes and peripheral mononuclear leukocytes 
in cancer patients. International Journal of Cancer 42:712-714, 1988. 
Economou, J.S., McBride, W.H., Essner, R., Rhoades, K.R., Golub, S., Holmes, E.C., 
Morton, D.L. Tumor necrosis factor production by interleukin-2 activated 
macrophages i_n vitro and i_Q vivo . Immunology, 67:514-519-1989. 
Essner, R., Rhoades, K., McBride, W.H., Morton, D.L., Economou, J.S. IL-4 
downregulates IL-1 and TNF gene expression in human monocytes. Journal of 
Immunology 1^: 3857-3861, 1989. 
Economou, J.S., Rhoades, K., Essner, R., McBride, W.H., Gasson, J.C., Morton, D.L. 
Genetic analysis of the human tumor necrosis factora/cachectin promoter region 
in a macrophage cell line. Journal of Experimental Medicine, 170:321-326, 1989. 
Economou, J.S. , Essner, R., Rhoades, K., Yamada,T., Swisher, S., Holmes, E.C., 
Golub, S., Morton, D.L. Genetic analysis of tumor necrosis factor promoter 
function in human tumor-infiltrating lymphocytes and other cell lines. Surgical 
Forum 40:448-452, 1989. 
Recombinant DNA Research, Volume 15 
[567] 
