* * * TABLE OF CONTENTS * * * 
I. Call to Order 1 
II. Minutes of February 10-11, 1992, Meeting 1 
III. Report on Human Gene Transfer Protocols Entitled: (1) Autologous Bone 
Marrow Transplant for Children with Acute Myelogenous Leukemia (AML) in 
First Complete Remission: Use of Marker Genes to Investigate the Biology 
of Marrow Reconstitution and the Mechanism of Relapse, (2) A Phase I /II 
Trial of High-Dose Carboplatin and Etoposide with Autologous Marrow Support 
for Treatment of Stage D Neuroblastoma in First Remission: Use of Marker to 
Investigate the Biology of Marrow Reconstitution and the Mechanism of Relapse, 
and (3) A Phase II Trial of High-Dose Carboplatin and Etoposide with Autologous 
Marrow Support for Treatment of Relapse/Refractory Neuroblastoma Without 
Apparent Bone Marrow Involvement /Dr. Brenner 1 
IV. Proposed Addition to Appendix D of the NIH Guidelines Regarding A Human Gene 
Transfer Protocol Entitled: A Phase I Study of Cytokine-Gene Modified Autologous 
Neuroblastoma Cells for Treatment of Relapsed/Refractory Neuroblastoma /Dr. Brenner . 3 
V. Proposed Addition to Appendix D of the NIH Guidelines Regarding a Human Gene 
Therapy Protocol Entitled: Gene Therapy for the Treatment of Brain Tumors 
Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous 
Ganciclovir /Dr. Oldfield 10 
VI. Proposed Addition to Appendix D of the NIH Guidelines Regarding Human Gene 
Transfer Protocols Entitled: (1) Treatment of HIV Infection with Transplantation 
of Genetically Altered Syngeneic Peripheral Blood Lymphocytes (PBL) and (2) 
Treatment of HIV Infection with Reinfusion of Genetically Altered Autologous PBL 
/Dr. Smith 18 
VII. Proposed Addition to Appendix D of the NIH Guidelines Regarding a Gene Transfer 
Protocol Entitled: Use of Two Retroviral Markers to Test Relative Contribution 
of Marrow and Peripheral Blood Autologous Cells to Recovery After Preparative 
Therapy /Dr. Deisseroth 26 
VIII. Report from the Working Group on Data Management 36 
IX. Proposed Categories of Gene Transfer 37 
X. Proposed Addition to Appendix D of the NIH Guidelines Regarding Two Human Gene 
Therapy Protocols Entitled: (1) Immunization with HLA-A2 Matched Allogeneic 
Recombinant DNA Research, Volume 15 
[665] 
