Recombinant DNA Advisory Committee - 06/1-2/92 
Dr. Anderson agreed with Mr. Capron's proposal that there be a mandatory deadline for 
the submission of protocols 8 weeks prior to the RAC meeting. 
Dr. Krogstad's submission proposal suggested that the RAC enforce a 20 page limitation 
for protocols, excluding tables, figures, and manuscripts. Dr. Post suggested that 20 
pages may be too strict of a requirement for investigators. Dr. Post suggested that the 
word Appendices be included in the list of additional material permitted as part of the 
original submission. 
Dr. Kelley agreed with Mr. Capron's schedule and suggested that no correspondence be 
accepted during the 2 week time period immediately preceding the RAC meeting. He 
acknowledged the importance of implementing the 20 page limitation on protocol 
submissions. Dr. W. French Anderson added that a 20 page limitation would be an 
acceptable criterion for investigators to follow provided that the page limitation does not 
include appendices, figures, and tables. Discussion ensued regarding the timeframe that 
investigators will assigned for their oral presentations. 
Dr. D. Miller suggested that a section should be included in the submissions 
requirements document formalizing vector requirements, i.e., a description of the 
elements, the sources it is derived form, and the method of sequence compilation. In 
addition, there should be a requirement that 3 disks containing the vector sequence, in 
ASCII format, should be forwarded to ORDA in order to screen for open reading 
frames, etc. 
Dr. Geiduschek suggested that an overview should be included as part of the submission 
requirements. Dr. Parkman stated that if the 2 week response deadline is enforced, than 
all of the reviewer's questions and investigator's responses will be included as part of the 
meeting materials. Since all of the RAC members will have had the opportunity to 
review these materials, than a 10 minute overview would be a capitulation of the same 
information. 
Dr. Schaechter reminded the RAC members that Dr. Krogstad's document is a guideline 
for submissions requirements and is not intended as a set of rules and regulations. The 
amount of time investigators require to present their proposals will vary. The RAC 
cannot dictate the time that will be required for investigators to adequately present the 
scientific overview. 
Dr. Kelley requested a change regarding the reviewers recommendation of the protocol. 
The guidelines suggest that the primary reviewer will indicate that a protocol is 
acceptable, acceptable with specific revisions, or unacceptable. Another category needs 
to be added: (1) to be determined , or (2) revise the acceptable with specific revisions 
category to acceptable depending on the outcome of the discussion by the RAC. He also 
Recombinant DNA Research, Volume 15 
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