To see if the treatment is working, we will do CAT scans, MRIs, or bone scans 6 weeks after 
treatment starts. We will also take a bone marrow biopsy. If the neuroblastoma is not 
responding, we will offer you (your child) treatment with chemotherapy and/or radiation 
therapy. If it is working, you (your child) may receive more courses of this treatment. 
We will follow your (your child’s) progress for a long time. You (your child) will need to 
be examined each year for 14 years. After the first 4 years this can be done by your (your 
child’s) local doctor. A blood sample (about 1 teaspoon) will be taken at each exam. 
SIDE EFFECTS 
In animal studies, and in people who have gotten treatments like this, the only side effect 
has been swelling and redness where the cells are injected. This went away in 1 to 3 weeks. 
IL-2 given in other ways can cause nausea, fever, or low blood pressure. We do not think 
this will happen because the modified cancer cells will produce only small amounts of IL-2. 
But it is possible. 
The mouse virus that is put in the cancer cells has no known side effects. It is possible that 
it might keep some antibiotics from working. It is also possible that the virus might "recover" 
and be able to grow, and it might cause another cancer. We think this is very unlikely but 
we cannot be sure it will not happen. 
There may be other side effects of this treatment that we do not know about yet. We will 
watch you (your child) very carefully for any side effects. If there are bad side effects, we 
will either use fewer cells in the next treatment, or stop the treatment. Also, if we find out 
the treatment isn’t working, we will stop the study. 
RISKS AND BENEFITS 
We do not know if this treatment will work. The possible benefit of being in this study is 
that your (your child’s) immune system may begin to kill the cancer cells, making the 
neuroblastoma grow more slowly or go away. 
The risks of the study are the possible side effects listed above. Also, it is possible that the 
cancer cells we put in your skin may keep growing instead of being killed. We will give you 
(your child) chemotherapy or radiation after the injections, but this may not kill all the cells 
we injected. 
If you do not want to be in this study, you may chose to have no further treatment or to have 
treatment with chemotherapy or radiation immediately. 
Recombinant DNA Research, Volume 15 
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