FF PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR: 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants listed on page 2. Begin with the Principal 
Investigator/Program Director. Photocopy this page for each person. 
NAME 
POSITION TITLE 
BIRTHDATE (Mo., Day, Yr.) 
Member, 
BRENNER, Malcolm Keith 
Hematology /Oncology 
Auaust 4, 1951 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
University of Cambridge 
Membership, Royal College of Physicians 
University of Cambridge 
Membership, Royal College of Pathologists 
Fellowship, Royal College of Physicians 
MA,MB, BCh 
MRCP 
PhD 
MRCPath 
FRCP 
.r 1975 
1977 
1981 
1988 
1990 
Medicine 
Medicine 
Immunology 
Haematology 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, 
and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles and com- 
plete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT 
1976 
1977 
1977- 78 
1978- 81 
1981-83 
1983-85 
1985-89 
1990 to 
present 
1990 to 
present 
pages 
Rouse Physician to Professor M.D. Milne, Westminster Hospital, London, U.K. 
Senior House Officer to Professor J.P. Shillingf ord, Hammersmith Hospital, and 
Royal Postgraduate Medical School, London 
Senior House Officer to Professor M. Turner Warwick and Dr. P. Cole, Brompton 
Hospital, London 
Medical Registrar to Professor A.F. Lant and Dr. L.W. Loughridge, Westminster 
Hospital, London, U.K. 
Medical Research Council Training (MRC) Fellow, Division of Immunology, 
Department of Pathology, Cambridge University, U.K. 
MRC Clinical Scientist, Honorary Senior Registrar, Northwick Park Hospital, 
and Clinical Research Centre, London 
Lecturer in Haematology, Royal Free Hospital and Hospital for Sick Children, 
Great Ormond Street, London 
Senior Lecturer, Honorary Consultant Haematologist (Deputy Director, BMT 
Program) Royal Free Hospital, London, U.K. 
Professor, Departments of Pediatrics and Medicine, University of Tennessee, 
Memphis, Tennessee 
Member, Hematology /Oncology , and Director, Bone Marrow Transplant Program, St. 
Jude Children's Research Hospital, Memphis, Tennessee 
SELECTED PUBLICATIONS (of 130 total) 
Wimperis JZ, Brenner MK, Prentice HG, Reittie JE, Patterson J, Karayiannis P, Griffiths 
PD, Hoffbrand AV. Transfer of a functioning humoral immune system in 
transplantation of T lymphocyte depleted bone marrow. Lancet i: 339-343, 1986. 
Malkovsky M, Brenner MK, Hunt R, Rastan S, Dore C, Brown S, North ME, Asherson GL, 
Prentice HG, Medawar P. T cell depletion of allogeneic bone marrow prevents 
acceleration of graft versus host disease induced by exogenous IL-2. Cell Immunol 
103:476-481, 1986. 
Brenner MK, Vyakarnam A, Reittie JE, Wimperis JZ, Grob JP, Hoffbrand AV, Prentice HG. 
Human large granular lymphocytes induce immunoglobulin synthesis after marrow 
transplantation. Eur J Immunol 17:43-47, 1987. 
Grob J-P, Grundy JE, Prentice HG, Griffiths PD, Tate T, Wimperis JZ, Brenner MK. Immune 
donors can protect marrow transplant recipients from severe cytomegalovirus 
infections. Lancet i:774-776, 1987. 
Wimperis JZ, Brenner MK, Prentice HG, Thompson EJ, Hoffbrand AV. B cell development and 
regulation after T-cell depleted marrow transplantation. J Immunol 138:2445-2450, 
1987. 
Cordingley FT, Bianchi A, Hoffbrand AV, Reittie JE, Heslop HE, Vyakarnam A, Turner M, 
Meager A, Brenner MK. Tumour necrosis factor as an autocrine tumour growth factor 
for chronic B-cell malignancies. Lancet i:1969-1971, 1988. 
Heslop HE, Price GE, Prentice HG, Cordingley FT, Webster ADB , Hoffbrand AV, Brenner MK. 
In vitro analysis of the interactions of recombinant IL2 with regenerating lymphoid 
PHS 398 (Rev. 10/88) Pa gn ~ ^ 
•Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 5a, 5b. 
Recombinant DNA Research, Volume 15 
[775] 
