PROPOSAL FOR A CLINICAL RESEARCH PROJECT 
Project Title: Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral 
Transduction with the Thymidine Kinase Gene and Intravenous 
Ganciclovir. 
Principal Investigator: 
Edward H. Oldfield, M.D., Chief, Surgical Neurology Branch, NINDS 
Associate Investigators: Neurosurgery 
Zvi Ram, M.D., Surgical Neurology Branch, NINDS 
Hetty L. DeVroom, R.N., BS.N., SNB, NINDS 
Associate Investigators: Gene Therapy 
Kenneth W. Culver, M.D., Senior Clinical Investigator, DCBC, NCI 
R. Michael Blaese, M.D. Chief, Cellular Immunology Section, DCBDC, NCI 
Major Collaborators: 
W. French Anderson, M.D., Chief, Molecular Hematology Branch, NHLBI 
Richard Knazek, M.D., Vice President, Cellco Inc., Germantown, Md. 
Paul Tolstoshev, PhD, Vice President, Genetic Therapy Inc., Gaithersburg, Md. 
Estimated Duration of Study: 3 years. 
Number and Kind of Subiects: Number Sex Aae 
Normal 
Employee 
Patients 20 M & F >18 
TOTAL 2 0 
Recombinant DNA Research, Volume 15 
