This is a new technique that is currently being studied. The purpose of this study is 
to determine the safety of treatment with these altered melanoma cells. 
SIDE EFFECTS 
In previous studies with x-rayed tumor cell vaccinations at Memorial Hospital, the 
side effects have been redness and swelling at the site of the injection. No one has 
had allergic reactions to the vaccines. 
The virus used to incorporate the blueprint for IL-2 is not able to grow on its own. 
In a recent study at the National Cancer Institute a similar virus has been used. 
Only a few patients received the virus, but so far there have been no serious side 
effects. However, this is a very new technique and serious side effects may yet be 
seen. There is a very remote possibility that the irradiated tumor cells used for the 
vaccination produce a virus not detected with our screening methods. Should a 
virus be produced there is the possibility that you may develop symptoms of a viral 
infection. Members of this virus family are known to cause lymphomas in rodents. 
Should you suffer a severe reaction to the vaccinations, treatment will be 
discontinued. 
You will be informed of the progress of the research study. During the time that 
you participate, you will be informed of any new findings which might affect your 
willingness to continue. 
If you are injured as a result of your participation in this research study, emergency 
care, hospitalization and outpatient care will be available to you by the Hospital and 
billed to you as part of your medical expenses. No money will be provided by 
Memorial Hospital or as compensation for a research-related injury. 
BENEFITS 
Although we do hope that this research study will be of benefit, there is not much 
experience in treating cancer patients with this technique and we do not know if it 
will help you directly. 
FINANCIAL COST 
You are responsible for the costs of the physician visits, hospitalizations, and 
laboratory and diagnostic tests. There will be no charge for the vaccinations or the 
blood tests done to evaluate the immune response to the vaccinations. 
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Recombinant DNA Research, Volume 15 
