Recombinant DNA Advisory Committee - 03/1-2/93 
I. CALL TO ORDER 
Dr. Walters (Chair) called the meeting to order and stated that notice of this meeting 
was published in the Federal Register as required by the National Institutes of Health 
Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines). He 
noted that a quorum was present and outlined the order in which speakers would be 
recognized. The primary and secondary reviewers will present their comments regarding 
the protocol, followed by responses from the principal investigators (Pis). The Chair will 
then recognize other committee members, ad hoc consultants, other NIH and Federal 
employees, the public who have submitted written statements prior to the meeting, 
followed by the public at large. 
Dr. Walters welcomed the following new members of the Recombinant DNA Advisory 
Committee (RAC): Ms. Abbey Meyers of the National Organization for Rare Disorders, 
New Fairfield, Connecticut; Dr. Arno Motulsky of the University of Washington Medical 
School, Seattle, Washington; Dr. Brian Smith of Yale University School of Medicine, 
New Haven, Connecticut; Dr. Stephen Straus of the NIH, Bethesda, Maryland; and Ms. 
Mariann Grossman of the University of Pennsylvania, Philadelphia, Pennsylvania. 
II. MINUTES OF THE DECEMBER 3-4, 1992, AND JANUARY 14, 1993, MEETINGS 
Dr. Walters called on Dr. DeLeon to review the minutes of the December 3-4, 1992, 
RAC meeting. Dr. DeLeon stated that the minutes were an accurate reflection of the 
committee's deliberations. Minor corrections were submitted by Dr. Geiduschek and Ms. 
Meyers. The RAC unanimously approved a motion made by Dr. DeLeon and seconded 
by Dr. Krogstad to accept the December 3-4, 1992, RAC minutes with the inclusion of 
minor grammatical changes by a vote of 19 in favor, 0 opposed, and no abstentions. 
Dr. Walters called on Dr. Chase to review the minutes of the January 14, 1993, RAC 
meeting. Dr. Chase stated that the minutes were an accurate reflection of the 
committee's deliberations. Minor corrections were submitted by Drs. Chase, Geiduschek, 
Zallen, and Carmen. The RAC unanimously approved a motion, made by Dr. 
Dronamraju and seconded by Dr. Zallen to accept the January 14, 1993, RAC minutes 
with the inclusion of minor grammatical changes by a vote of 19 in favor, 0 opposed, and 
no abstentions. 
III. ADDITION TO APPENDIX D OF THE NIH GUIDELINES REGARDING A HUMAN 
GENE THERAPY PROTOCOL ENTITLED: GENE THERAPY FOR THE 
TREATMENT OF MALIGNANT BRAIN TUMORS WITH IN VIVO TUMOR 
TRANSDUCTION WITH THE HERPES SIMPLEX-THYMIDINE KINASE 
GENE/GANCICLOVIR SYSTEM /DRS. CULVER AND VAN GILDER 
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Recombinant DNA Research, Volume 17 
