CLINICAL RESEARCH PROJECT Date; 3 January, 1993 
To: Recombinant DNA Advisory Committee 
Recommended by: Keith McRoberts, Ph.D., Director Research and Innovations, IMMC 
Project Title: Gene Therapy for the Treatment of Malignant Brain Tumors with 
In vivo Tumor Transduction with the Herpes Simplex 
Thymidine Kinase Gene/Ganciclovir System. 
Identifying Words: gene transfer, retrovirus, brain metastasis, glioblastoma 
Co-Principal Investigators: 
Gene Therapy: Kenneth W. Culver, M.D., Director, 
Gene Therapy Research Institute, IMMC 
Neurosurgery: John Van Gilder, M.D., Chairman, 
Division of Neurosurgery, University of Iowa, College of Medicine 
Associate Investigators: 
Charles J. Link, M.D., Division of Molecular Oncology, IMMC 
Thomas Carlstrom M.D., Department of Neurosurgery, IMMC 
Thomas Buroker, D.O., Oncologist, IMMC 
William Yuh, M.D., Department of Radiology, Univ.Iowa College Med. 
Kevin Koch, M.D., Department of Radiology, IMMC 
Company Sponsor: 
Genetic Therapy Incorporated, Gaithesburg MD 
Collaborator: 
R. Michael Blaese, M.D. Chief, Cellular Immunology Section, NCI 
Subject of Study Number 
Patients 40 
Sex Range 
M or F >18 years 
Project Uses Ionizing Radiation: 
Yes 
— 
No 
Project involves use of Durable Power of Attorney _X — 
Yes No 
Multi-institutional Project: X (Approvals secured) 
Yes No 
Recombinant DNA Research, Volume 17 
