TABLE OF CONTENTS 
Page 
1.0 CHECKLIST FOR PATIENT ELIGIBILITY PRIOR TO BMT 3 
2.0 OBJECTIVES 3 
3.0 BACKGROUND AND RATIONALE 4 
4.0 STUDY DESIGN 9 
5.0 PATIENT ELIGIBILITY H 
6.0 TREATMENT PLAN 12 
7.0 PATIENT EVALUATION 13 
8.0 EVALUATION DURING STUDY 14 
9.0 STATISTICAL CONSIDERATIONS 14 
10.0 STUDY INTERPRETATION 16 
11.0 OFF-STUDY CRITERIA 17 
12.0 RECORDS TO BE KEPT 17 
13.0 REPORTING REQUIREMENTS 17 
14.0 INFORMED CONSENT 18 
15.0 REFERENCES 18 
16.0 PARENT'S/PATIENT'S SUMMARY STATEMENT 23 
17.0 STATEMENT OF UNDERSTANDING 26 
APPENDIX 1 PREPARATION AND TRANSDUCTION OF CELL LINES 29 
APPENDIX 2: COMMON NIH TOXICITY CRITERIA 31 
APPENDIX 3: SEATTLE GVHD CRITERIA: 34 
Recombinant DNA Research, Volume 17 [197] 
