Performance Status Definition 
ECOG Kamofsky 
Grade Score Activity 
0 90-100 Up and about, no restriction. 
1 70-90 Ambulatory, no strenuous activity. 
2 50-70 Ambulatory, capable of self-care appropriate 
for age. Up and about >50% of time, but 
unable to carry out any physical activities or 
attend school. 
3 30-50 Limited self-care only. Up and about <50% 
of time. 
4 <30 Disabled, no self care. Bedridden or confined 
to chair. 
6.0 TREATMENT PLAN 
6.1 Cell Administration 
Cell administration will be as follows: 
EBV specific gene-marked T cells will be given by intravenous injection in 
RPMI with 5% HSA at weekly intervals x 4 from Day 45 at the following dose 
schedules. Three to six patients will be treated in each group (See Section 9). 
Group One 
Day 45 10 7 cells/m 2 
Day 52 10 7 cells/m 2 
Day 59 5 x 10 7 cells/m 2 
Day 66 5 x 10 7 cells/m 2 
Group Two 
Day 45 5 x 10 7 cells/m 2 
Day 52 5 x 10 7 cells/m 2 
Day 59 10 8 cells/m 2 
Day 66 10 8 cells/m 2 
Group Three 
Day 45 10 8 cells/m 2 
Day 52 10 8 cells/m 2 
Day 59 5 x 10 8 cells/m 2 
Recombinant DNA Research, Volume 17 
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