First Occurrence of a Toxicity 
The first occurrence of a toxicity (not previously reported, no matter what the grade 
(1-5), must be reported by phone to the OPRR, Charles R. McCarthy (301) 496-7005, 
within 24 hours of the event. An Adverse Drug Reaction Form must be sent to the 
OPRR, Charles R. McCarthy, within 10 working days. 
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