possible that the mouse virus might "recover" in the cell and be able to grow; it might even 
cause cancer. We think this is very unlikely but we cannot rule it out yet. 
BENEFITS 
The benefits of this purging/marker study would be that we could learn what methods of 
purging work best. This will help us plan better ways of treating AML. If you (your child) 
needed another transplant in the future, these changes might help you (your child). 
Otherwise, what we learn might lead to better treatment for other patients with AML. 
BONE MARROW TRANSPLANT 
You (your child) will rest for one day after the chemotherapy. Then the bone marrow that 
was taken out before will be put back through an IV catheter. So that we can study the 
marked cells, we will take a little extra blood after the marrow is put back. The extra blood 
taken will be about 20 mL (1 tablespoon) once or twice a week for 6 weeks. We will also 
take extra blood monthly for 6 months, every six months for 2 years, and then once a year 
for 2 years. 
LONG-TERM FOLLOW UP 
We will follow your (your child's) progress over a long period. You (your child) will need 
to be examined yearly for 14 years after the transplant. After the first 4 years this can be 
done by your (your child's) local doctor. A teaspoon of blood will be taken at each exam. 
CONFIDENTIALITY 
Your (your child's) case will be treated in complete confidence, unless you specifically agree 
otherwise. However, approved people from the Food and Drug Administration and 
National Instuties of Health, as well as St. Jude clinical staff may review the charts. 
SIDE EFFECTS 
Purging 
May delay or prevent the graft from taking. May increase the risk of infection or bleeding. 
Virus - No known side effects. 
( Possibly could cause a few antibiotics such as neomycin or amikacin not to work or the 
virus could "recover" and grow or could make cells cancerous) 
ALTERNATIVES TO PURGING/MARKING 
If you do not wish to have purging/marking treatment you/your child can still have high- 
dose chemotherapy and bone marrow transplant with untreated marrow. 
If you wish to have purging but not gene marking your/your child's marrow can be treated 
with the drug 4HC alone. 
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Recombinant DNA Research, Volume 17 
