ASSENT FORM - PATIENT AGE 7-18 YEARS FOR BONE MARROW TRANSPLANT 
ASSENT 
You are in remission from AML. This means we cannot see any leukemia cells in your bone 
marrow or spinal fluid. There is a good chance your leukemia will return if you do not have 
further treatment. We would like to stop your leukemia from coming back by performing 
a bone marrow transplant using your own bone marrow. Before we do the bone marrow 
transplant we will examine you to be sure you can have the transplant. We will also test you 
for certain viruses including the virus for AIDS. 
We will take a small part of your bone marrow out while you are asleep in the operating 
room. Since you will be sleeping, you will not feel us take the marrow. When you wake up, 
you may have some pain but you will receive medicine to make this feel better. Your bone 
marrow will be frozen for later use. 
At a later time, you will come into the hospital and receive high-dose anticancer drugs that 
will stop your blood-forming cells from growing. We hope these drugs will get rid of your 
leukemia and stop it from coming back. We will then thaw your marrow and give it back 
to you so your blood forming cells will grow again. 
MARROW PURGING AND MARKING 
If you agree, we will take a part (two-thirds) of the bone marrow that we have removed and 
mix it with special viruses. These special viruses are like a taxicab and drop a marker in 
your cells. We can watch the marked cells grow back after your bone marrow transplant. 
We will then treat your marrow with two drugs to try and kill any leukemia cells left behind 
in your marrow. We hope that the markers will let us learn more about your leukemia and 
our treatment and may one day help us to better treat you or others. 
HIGH-DOSE CHEMOTHERAPY 
You will receive a drug called busulfan by mouth 4 times each day for four days (total 16 
times). You will then receive a second drug, called Cytoxan, by vein daily for four days. 
If leukemic cells are found in your spinal fluid, you will also have spinal taps with a drug 
called methotrexate. 
BONE MARROW TRANSPLANT 
After the high-dose drug therapy you will have a day of rest. Then your frozen bone 
marrow will be thawed and given back to you by your central catheter. An extra amount 
of blood will be taken once or twice a week for six weeks, and then monthly for six months, 
every six months for two years, and once a year for two more years. This will help us to test 
how the marrow cells are growing. You will also have a total of eight bone marrow 
aspirates to see how well your marrow is growing and whether the marked cells are present. 
If you had leukemic cells in your spinal fluid before transplant, you will have an additional 
five spinal taps after the transplant is completed. The maximum number of spinal taps you 
will have is 10 (unless your leukemia returns). 
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