CONTINUATION PAGE: STAY WITHIN MARGINS INDICATED 
Principal Investigator/Program Director (Last, first, middle): 
BRENNER, Malcolm K. 
Heslop HE, Gottlieb DJ, Bianchi ACM, Meager A, Prentice HG, Mehta AB, Hoffbrand AV, 
Brenner MK. In vivo induction of gamma interferon and tumour necrosis factor by 
Interleukin 2 infusion following intensive chemotherapy or autologous marrow 
transplantation. Blood 74:1374-1380, 1989. 
Gottlieb DJ, Prentice HG, Heslop HE, Bello-Fernandez C, Bianchi ACM, Galazka A, Brenner 
MK. Effects of recombinant Interleukin 2 administration on cytotoxic function 
following high dose chemoradiotherapy for hematological malignancy. Blood 74:2335- 
2342, 1989. 
Duncombe AS, Heslop HE, Turner M, Meager A, Priest R, Exley T, Brenner MK. Tumour 
necrosis factor mediates autocrine growth inhibition in a chronic leukemia. J 
Immunol 143:3828-3834, 1989. 
Bianchi ACM, Heslop HE, Veys P, Macey M, Holland M, Prentice HG, Brenner MK. Enhancement 
of monoclonal antibody dependent cell mediated cytotoxicity by IL2 and GMCSF . Br 
J Haematol 73:468-474, 1989. 
Wimperis JZ, Gottlieb D, Duncombe AS, Heslop HE, Prentice HG, Brenner MK. Requirements 
for the adoptive transfer of antibody responses to a priming antigen in man. J 
Immunol 144:541-547, 1990. 
Gignac SM, Buschle M, Heslop HE, Brenner MK, Hoffbrand AV, Drexler HG. Delayed induction 
of proto-oncogene expression in B-CLL cells in response to Tumour Necrosis Factor. 
Leuk Lymph 3:37-43, 1990. 
Gottlieb DJ, Prentice HG, Mehta AB, Galazka AR, Heslop HE, Hoffbrand AV, Brenner MK. 
Malignant plasma cells are sensitive to MHC unrestricted lysis: Preclinical and 
clinical studies of Interleukin 2 in the treatment of multiple myeloma. Br J 
Haematol 75:499-505, 1990. 
Duncombe AS, Meager A, Prentice HG, Grundy JE, Heslop HE, Hoffbrand AV, Brenner MK. 
Gamma interferon and tumour necrosis factor production following bone marrow 
transplantation is augmented by exposure to marrow fibroblasts infected with CMV. 
Blood 76:1046-1053, 1990. 
Heslop HE, Bianchi ACM, Cordingley FT, Turner M, De Mel WCP, Hoffbrand AV, Brenner MK. 
Effects of a-interferon on autocrine growth factor loops in B lymphoprolif erative 
disorders. J Exp Med 172:1729-1734, 1990. 
Bello-Fernandez C, Bird C, Heslop HE, Gottlieb DJ, Reittie JE, Rill DM, Holland M, 
Prentice HG, Brenner MK. Homeostatic action of Interleukin 4 on endogenous and 
rIL2 induced activated killer cell function. Blood 77:1283-1289, 1991. 
Heslop HE, Duncombe AS, Reittie JE, Bello-Fernandez C, Gottlieb DJ, Prentice HG, 
Hoffbrand AV, Brenner MK. Interleukin 2 infusion after autologous bone marrow 
transplantation accelerates hemopoietic regeneration. Transplant Proc 23:1704- 
1705, 1991. 
Oblakowski P, Bello-Fernandez C, Reittie JE, Heslop HE, Galatowicz S, Veys P, Wilkes S, 
Hazlehurst G, Hoffbrand AV, Brenner MK. Possible mechanism of selective killing 
of myeloid leukemic blast cells by lymphokine-activated killer cells. Blood 
77:1996-2001, 1991. 
Heslop HE, Brenner MK, Ganeshaguru K, Hoffbrand AV. Possible mechanism of action of 
interferon alpha in chronic B-cell malignancies. Br J Haematol 79:14-16, 1991. 
Brenner MK, Heslop HE. Graft versus host reactions and bone marrow transplantation. 
Curr Opin Immunol 3:752-757, 1991. 
Brenner MK, Heslop HE. Immunotherapy of leukemia. Leukemia 6:76-79, 1992. 
Gottlieb DJ, Bello-Fernandez C, Heslop HE, Prentice HG, Brenner MK. Interleukin 2 
infusion abrogates humoral immunity. Clin Exp Immunol 87:493-498, 1992. 
Rencher SD, Hanif I, Heslop HE, Turner V, Brenner MK, Hurwitz JL. Reconstitution of the 
T-cell receptor a/3 repertoire in recipients of allogeneic bone marrow transplant. 
Bone Marrow Transplant 10:521-527, 1992. 
Krance RA, Heslop HE, Mahmoud H, Ribeiro RC, Douglass EC, Hurwitz CA, Santana VM, Kun, 
L, Horowitz MM, Brenner MK. Anti-pan T-lymphocytic ricin A chain immunotoxin (H65- 
RTA ) and methy lprednisolone for acute graf t-versus-host disease prophylaxis 
following allogeneic bone marorow transplantation from HLA+DR identical and MLC 
nonreactive sibling donors. Bone Marrow Transplant (in press). 
Heslop HE, Krance RA, Parham D, Brenner MK. Viruses and transplantation. Encyclopedia 
of Virology (in press). 
PHS 398 (Rev 9/91) Page . . 17 
Numoer oflC2 ? 7 : S1 i0cu,lvel y' al ,h e Dotiom throughout the application. Do nof use suffixesTu3?.4iGQn&bin&nt DNA iN.CSC3.rCil, VOlUITlC 1/ 
