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Principal Investigator/Program Director (Last, first, middle): 
BRENNER, Malcolm K. 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
IHLE, James N. 
POSITION TITLE 
Chairman, Department of Biology 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Iowa State University 
B.S. 
1967 
Zoology 
University of Georgia 
M.S. 
1969 
Biochemistry 
University of Georgia 
Ph.D. 
1971 
Biochemistry 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
1971- 72 
1972- 73 
1973- 75 
1975-79 
1978- 88 
1979- 88 
1979-88 
1988 to 
Present 
1988 to 
Present 
Postdoctoral Fellow, Oak Ridge National Laboratory, Tennessee 
Postdoctoral Fellow, American Cancer Society, Oak Ridge, Tennessee 
Staff Scientist, Oak Ridge National Laboratory, Tennessee 
Head, Immunobiology of Viral Carcinogenesis Section, Cancer Biology Program, 
NCI-Frederick Cancer Research Facility, Frederick, Maryland 
Associate, Department of Epidemiology, Division of Infectious Diseases, 
Johns Hopkins University, Baltimore, Maryland 
Associate, Department of Biochemistry, George Washington University Medical 
School, Washington, DC 
Head and Principal Research Scientist, Molecular Mechanisms in T-Cell 
Leukemogenesis Section, NCI-Frederick Cancer Research Facility, BRI-Basic 
Research Program, Frederick, Maryland 
Professor, Department of Biochemistry, University of Tennessee, Memphis, 
Tennessee 
Chairman, Department of Biochemistry, St. Jude Children's Research Hospital, 
Memphis, Tennessee 
MOST RECENT PUBLICATIONS (192) 
Keller JR, Ihle JN. Unique pathway of IL-3-driven hemopoietic differentiation. 
Immunol 143:4025-4033, 1989. 
Ihle JN, Morishita K, Parker DS, Bartholomew C, Askew D< Buchberg A, Jenkins NA, Copeland 
N, Weinstein Y. Mechanisms in the transformation of lL-3-dependent hematopoietic stem 
cells. Curr Top Microbiol Immunol 149:59-59, 1989. 
Iyer A, Kmiecik TE, Park M, Daar I, Blair D, Dunn KJ, Sutrave P, Ihle JN, Bodescot M, 
Vande Woude GF. Structure, tissue-specific expression, and transforming activity of he 
mouse met protooncogene. Cell Growth and Differentiation. 1:87-95, 1990. 
Matsugi T, Morishita K, Ihle JN. Identification, nuclear localization, and DNA-binding 
activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Mol 
Cell Biol 10:1259-1264, 1990. 
Ihle JN, Morishita K, 
the transformation of 
Bartholomew C, Matsugi T, Askew D. Phenotypes and mechanisms in 
hematopoietic cells. Int J Cell Cloning 8:130-146, 1990. 
a 
PHS 39 
Number p; 
Morshita K, Parganaa E, Douglass EC, Ihle JN. Unique expression of the human Evi-1 gene 
in an endometrial carcinoma cell line: Sequence of cDNAs and structure of alternatively 
^ . QfiT-971 ■ 1990. 
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[ 279 ] 
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