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Principal Investigator/Program Director (Last, first, middle): 
BRENNER, Malcolm K. 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
POSITION TITLE 
Associate Member, Hematology-Oncology 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Catholic University of Puerto Rico, 
B.S. 
1974 
Biology 
Ponce, Puerto Rico 
University of Puerto Rico School of 
Medicine, San Juan, Puerto Rico 
M.D. 
1978 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory comrViittee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES 
The Johns Hopkins Hospital, Baltimore, Maryland 
1979- 80 Assistant Resident, Department of Pediatrics 
1980- 81 Senior Assistant Resident, Department of Pediatrics 
1981- 84 Clinical Fellow in Oncology-Hematology 
1981-84 Clinical Fellow in Pediatrics 
1984- 85 Clinical Fellow in Pharmacology, St. Jude Children's Research Hospital, 
Memphis, Tennessee 
1985- 92 Assistant Member in Hematology/Oncology, St. Jude Children's Research 
Hospital, Memphis, Tennessee 
1986 to Associate Professor, Department of Pediatrics, University of Tennessee, 
present Memphis, Memphis, Tennessee 
1992 to Associate Member in Hematology/Oncology, St. Jude Children's Research 
present Hospital, Memphis, Tennessee 
PUBLICATIONS (from 27) 
Rao BN, Santana VM, Fleming ID, Pratt CB, Shapiro D, Fontanesi J, Kumar M, Austin BA. 
Management and prognosis of head and neck sarcomas. Am J Surg 158:373—377, 1989. 
Santana VM, Dodge RK, Crist WM, Rivera GK, Look AT, Behm FG, Raimondi SC, Pui C-H. 
Presenting features and treatment outcome of adolescents with acute lymphoblastic 
leukemia. Leukemia 4:87-90, 1990. 
Mirro J, Kalwinsky D, Grier HE, Santana VM, Mason C, Murphy SM, Dahl GV. Effective 
reinduction therapy for acute nonlymphoid leukemia using simultaneous continuous 
Infusions of teniposide and amsacrine. Cancer Chemother Pharmacol 24:123—127, 1989. 
Fleming ID, Turk PS, Murphy SB, Crist WM, Santana VM, Rao BN. Surgical implications of 
primary gastrointestinal lymphoma of childhood. Arch Surg 125:252-256, 1990. 
Kalwinsky DK, Raimondi SC, Schell MJ, Mirro J Jr, Santana VM, Behm F, Dahl GV, Williams 
D. Prognostic importance of cytogenetic subgroups in de novo pediatric acute 
nonlymphocytic leukemia. J Clin Oncol 8:75-83, 1990. 
Santana VM, Mirro J, Harwood FC, Cherrie J, Schell M, Kalwinsky D, Blakley RL. A phase 
I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia. 
J Clin Oncol 9:416-422, 1991. 
1398 (Rev. 9/91) TA _ , X? 
(Form Pape 6) Page 
suffixes such as 3a, 3b. 
