7.3 STUDY OBSERVATIONS AND FREQUENCY 
PARAMETER 
FREQUENCY OF EVALUATION 
I. CLINICAL TOXICITY 
History and physical examination D 
Vital Signs and Weight A 
Performance status A 
HCT, WBC, platelet counts B 
Differential, absolute eosinophil count B 
Electrolytes B 
BUN, creatinine B 
Total protein/albumin C 
Calcium/phosphate C 
Alkaline phosphatase C 
Total direct bilirubin C 
SGOT , SGPT C 
Uric acid C 
Glucose B 
ESR K 
Urinalysis B 
Urine Micro-albumin Assay B 
Chest x-ray M 
EKG M 
Baseline DPG Renal Scan F 
Dermatologic Photography at Vaccine Site A 
Brief Symptom Inventory (Psychological Questionnaire) 0 
II. GM-CSF PHARMACOKINETICS 
Serum GM-CSF Levels L 
III. AUTO-IMMUNE TOXICITY 
Anti-nuclear antibody D 
Rheumatoid Factor D 
Thyroid Function Tests (TSH, T3,T4) D 
Anti-thyroid Antibodies D 
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