8.0 TUMOR RESPONSE CRITERIA 
8.1 Complete Response - Complete disappearance of all clinically 
detectable malignant disease for at least four weeks. Patients with bony 
metastases should have normalization of all bone x-rays. 
8-2 Partial Response - Greater than or equal to 50% decrease in the sum 
of the metastatic sites for at least 4 weeks without increase in size of any 
area of known malignant disease or appearance of new areas of malignant 
disease. 
8. 2. a. Measurable ( Bidemensional ) : 
Greater than or equal to 50% decrease in tumor size 
(multiplication of longest distance by the perpendicular distance) 
for at least 4 weeks without increase in size of any area of known 
malignant disease or appearance of new areas of lignant disease. 
8.2. b. Measurable (Unidimensional ); 
Greater than or equal to 30% decrease in linear tumor measurements 
for at least four weeks. 
8.2. C. Mediastinal and hilar responses : 
A - On-study width 
B - Normal width 
C - Width after treatment 
Partial Response if ( A-B) - (C-B )> 0.3 
(A-B) 
8 . 2 . d. Palpable Masses ; 
Palpable masses that can be measured in only one dimension 
may be evaluated for response by using this formula: 
PR if AHB > 0.3 
A 
3.2. e. Partial Response of Malignant Hepatomegaly 
(Liver > 5 cm below costal margin) 
Partial response has occurred if the liver 
measurements in the midclavicular lines (or 
other consistently used points from the tip of 
the xiphoid decrease by > 30%. 
Recombinant DNA Research, Volume 17 
[331] 
