could be helpful for research tests on the effects of the injections on 
your cancer, they will ask your permission to do a lymph node biopsy. You ' 
will be asked to read and sign another consent form for this minor surgery. 
You may refuse and continue on the study. 
t 
You will also receive x-rays such as CT scans or MRIs. After 
finishing the shots, your doctors will ask you to come for routine checkups jr 
to care for your medical needs, and to look for late side effects. If i 
healthy, you may take part in other experimental studies if the injections 
do not slow or stop your disease. 
RISKS AND DISCOMFORTS : You may have side effects from the injections. 
Common side effects could be skin reactions, pain, redness, swelling, f 
bleeding or ulcers at the injection sites. You may also experience fever, 
increase in your white blood cell count, swelling in your joints, general . 
swelling over your body, fluid in your lungs or around your heart, r 
weakness, diarrhea, bone pain, low red cell counts, kidney damage, forms of c 
arthritis, or changes in your thyroid. You may have side effects that we j 
do not yet know about. Finally, if you receive your cancer cells prepared . 
with the GM-CSF gene transfer, tests before the shots will check that ■ 
mouse viruses are not contaminating the cells. In theory, you could get a ’ 
viral infection from contaminated cells. We do not know what the long-term 
side effects are in humans. 
BENEFITS : These kidney cancer cell shots may stop your cancer, or slow it ' 
down. It is unlikely that these shots will cure your cancer. Your taking 
part in this study will help us to see if this approach to kidney cancer 
treatment is safe, and this knowlege might help cancer patients in the 
future . 
NEW INFORMATION : Any new information to your doctors during the course of 
this research that might affect your choice to continue as a research 
subject will be given to you. This includes new information about the , 
study procedures or physical reactions experienced by other patients ! 
involved in this study. 
COSTS AND PAYMENTS : The cell treatments, and special research tests will 
provided at no charge. All other laboratory, physician, or hospital costs 
not related to the performance of research during this study will be 
charged to your insurance company or to you. You will have been informed 
of the possible cost of treatment on this protocol although this is only an ' 
estimate. The Johns Hopkins University, The Johns Hopkins Hospital, and 
the Federal Government do not have any program to provide compensation to j 
you if you experience injury or other bad effects which are not the fault 
of the investigators. 
ALTERNATIVES TO PARTICIPATION ; You do not have to take part in this study. 
You can quit the study at anytime and continue your care at Johns Hopkins. 
If you do not want to be in this study, you can still receive your medical j 
care at Johns Hopkins. You may have surgery alone. Other treatments 
available are interleukin-2 if you have not been treated with this already 
and other experimental drugs. You can also decide not to receive any 
treatment at all. 
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