Under sterile conditions the kidney cancer cells will be grown and 
irradiated (X-rayed) so they can no longer grow or spread after 
injection under the skin. The cells are shipped back to Hopkins 
right before the time of injection in the Oncology Center. This 
procedure has been successful in 20 of 22 cases of renal cancer at 
Johns Hopkins in trial runs at this writing. In other words, you 
have a 8 to 9 chances in 10 of receiving cells once sent. If for 
any technical reason the process fails any safety standard set, you 
cannot receive treatment. 
Injections will be given in the Oncology Center. You can 
begin treatment after recovery from surgery-- between 3 to 6 weeks 
afterwards if there are no complications from the surgery making 
experimental treatment unsafe. You will be injected with between 
4 to 16 shots every 28 days unless there are side effects. You may 
be injected up to 3 months. You will get shots in your right 
thigh, the arm you don't write with, and left thigh, in that order. 
If there is evidence of any benefit and the dose assigned to you 
appears safe you can continue until cells run out. If your disease 
progresses during the study, your doctors will discuss with you 
other treatment options. 
You will be asked to see your doctors at Hopkins for routine 
check-ups regardless of what happens. The follow-up is first to 
continue your care and second to study the long-term side effects 
of the injections. 
4. FINANCES AND HOUSING FOR OUT OF TOWN PATIENTS 
As in the case of most cancer clinical trials at the Johns 
Hopkins Oncology Center your insurance company if you have one will 
be billed for medical costs of care related to kidney cancer 
patients. These costs, including surgery are about $19,000. The 
preparation of the cells and all aspects having to do with research 
tests will not be billed. Individual patients, depending on 
patient and family financial circumstances, can receive information 
and confidential advice on special arrangements on these matters 
from the Study's Social Worker, Mr. James Zabora at 410-955-2305. 
Housing and transportation from Johns Hopkins Oncology Center 
Housing to the Cancer Center for our out of town patients and 
families can be arranged at a minimal cost depending family 
circumstances. Mr. Zabora can provide you with this information as 
well. A patient care representative is on call 24 hours a day as 
will be your study doctors for concerns or questions. 
Recombinant DNA Research, Volume 17 
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