A Phase I Study of Gene Therapy of Cystic Fibrosis Utilizing a Replication 
Deficient Recombinant Adenovirus Vector to Deliver the Human Cystic 
Fibrosis Transmembrane Conductance Regulator cDNA to the Airways. 
Submitted to the NTH Recombinant DNA Advisory Committee 
January 4, 1993 
Children’s Hospital Medical Center 
Elland & Bethesda Avenues 
Cincinnati, Ohio 45229 
Investigators : 
Robert W. Wilmott, M.D. 
Associate Professor of Pediatrics 
Director of Pulmonary Medicine 
Children’s Hospital Medical Center 
Elland & Bethesda Avenues 
Cincinnati, OH 45229 
Jeffrey A. Whitsett, M.D. 
Professor of Pediatrics 
Director of Pulmonary Biology 
Children’s Hospital Medical Center 
Children’s Hospital Research Foundation 
Elland & Bethesda Avenues 
Cincinnati, OH 45229 
Bruce Trapnell, M.D. 
Director, Department of Virology 
Genetic Therapy, Inc. 
19 Firstfield Road 
Gaithersburg, MD 20878 
Co-Investigators 
John Cuppoletti, Ph.D. 
Associate Professor 
Physiology & Biophysics 
University of Cincinnati 
College of Medicine 
231 Bethesda Avenue 
Cincinnati, OH 45267 
Susan Wert, Ph.D. 
Director of Morphology Core 
Cystic Fibrosis RDP Center 
Division of Pulmonary Biology, 
Children’s Hospital Medical Center 
Elland & Bethesda Avenues 
Cincinnati, OH 45229 
Robert Baughman, M.D. 
Associate Professor 
Department of Medicine 
University of Cincinnati 
College of Medicine 
231 Bethesda Avenue 
Cincinnati, OH 45267 
Paul Tolstoshev, Ph.D. 
Director of Research 
Genetic Therapy, Inc. 
19 Firstfield Road 
Gaithersburg, MD 20878 
[356] 
Recombinant DNA Research, Volume 17 
