' 
: pp Principal Investigator/Program Director (Last, first, middle): 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME POSITION TITLE 
Jeffrey A. Whitsett, M.D. Professor of Pediatrics 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Colgate University, New York 
B.A. 
1969 
Chemistry 
Columbia University, New York 
M.D. 
1973 
Medicine 
Mt. Sinai Hospital, New York 
1973-76 
Internship-Residency 
Children’s Hospital, Cincinnati, OH 
1976-78 
Neonatal Fellowship 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
j honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project, 
j Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
j baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
i any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
j past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
Employment : 
1985-present Professor of Pediatrics, and Pharmacology and Cell Biophysics, University of 
Cincinnati; Director, Pulmonary Biology, Children’s Hospital Medical Center 
Publications: (Selected from 124 peer reviewed manuscripts) 
1. Whitsett, J.A., Pilot, T., Clark, J. and Weaver, T.E.: Induction of surfactant protein in fetal lung: 
effects of cAMP and dexamethasone on SAP-35 RNA and synthesis. J. Biol. Chem. 262:5256- 
5261, 1987. 
2. Glasser, S.W., Korfhagen-, T.R., Weaver, T., Pilot-Matias, T., Fox, J.L. and Whitsett, J.A.: cDNA and 
deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe). 
Proc. Natl. Acad. Sci. USA 84:4007-4011. 1987. 
3. Whitsett, J.A., Weaver, T.E., Lieberman, M.A., Clark, J.C. and Daugherty, C.: Differential effects 
of epidermal growth factor and transforming growth factor- p on synthesis of Mr =35,000 surfactant- 
associated protein in fetal lung. J. Biol. Chem. 262:7908-7913, 1987. 
4. Whitsett, J.A., Weaver, T.E.>Clark, J.C., Sawtell, N., Glasser, S.W., Korfhagen, T.R. and Hull, W.M.: 
Glucocorticoid enhances surfactant proteolipid Phe and pVal synthesis and RNA in fetal lung. J,. 
Biol. Chem. 262:15618-15623, 1987. 
5. Weaver, T.E., Sarin, V.K., Sawtell, N., Hull, W.M. and Whitsett, J.A.; Identification of surfactant 
proteolipid SP-B in human surfactant and fetal lung. J. Appl. Physiol. 65:982-987, 1988. 
6. Glasser, S.W., Korfhagen, T.R., Weaver, T.E., Clark, J., Pilot-Matias, T., Meuth, J., Fox, J.L. and 
Whitsett, J.A.: cDNA, deduced polypeptide structure and chromosomal assignment of human 
pulmonary surfactant proteolipid: SPL(pVal). J. Biol. Chem. 263:9-12. 1988. 
7. Weaver, T.E. and Whitsett, J.A.: Processing of hydrophobic pulmonary surfactant protein B in rat 
Type II cells. Am. J. Physiol. 257 fLuna Cell. Mol. Physiol. 1) : L100-L108, 1989. 
8. O’Reilly, M.A., Gazdar, A.F., Morris, R.E. and Whitsett, J.A.: Differential effects of glucocorticoid 
on expression of surfactant proteins in a human lung adenocarcinoma cell line. Biochim. Biophvs. 
Acta 970:194-204, 1988. 
9. Pilot-Matias, T.J., Kister, S.E., Fox, J.L, Kropp, K., Glasser, S.W. and Whitsett, J.A.: Structure and 
organization of the gene encoding human pulmonary surfactant proteolipid SP-B. DNA 8:75-86, 
1989. 
10. O’Reilly, M.A., Weaver, T.E., Pilot-Matias, T.J., Sarin, V.K., Gazdar, A.F . and Whitsett, J.A.: in vitro 
translation, post-translational processing and secretion of pulmonary surfactant protein B 
precursors. Biochim. Biophvs. Acta 1011:140-148, 1989. 
I 
PHS 398 (Rev. 9/91 ) (Form Pa 9 e 6 > Pa 9 e — 
Numoer sutt,xes such as 
3a. 
3b. 
[427] 
