These data are derived from transformed cells in an in vitro situation. 
However, the prediction that only a low percentage of cells must be corrected likely 
can be extrapolated to the in vivo situation with adenovirus. For example, the level 
of expression of transduced CFTR in these studies is generally below the level 
transduced with the adenoviral vector. Further, the level of cell-cell 
communication, i.e., via gap junctions, is similar in the in vivo situation to that 
measured in vitro. 
Recombinant DNA Research, Volume 17 
[467] 
