FF 
Principal Investigator/Program Director (Last, first, middle): 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
POSITION TITLE 
j Richard C. Boucher, M.D. 
1 
Professor of Medicine 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Yale University, New Haven, Cl' 
B.A. 
1966 
Physiol. Psych. 
Columbia University, New York, NY 
M.D. 
1970 
Medicine 
Columbia Presby. Hosp. New York, NY 
Int/Res 
1972 
Medicine 
Royal Victoria Hosp, Montreal, Canada 
Fellow 
1977 
Medicine 
I 
I 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
aasl three years and tpj’ppresentative 
Employment History: 
earlier publications pertinent to this application. 
DO NOT EXCEED TWO PAGES. 
1975 - 1977 
1977 - 1981 
1981 - 1985 
1985 - pres. 
1988 - pres. 
1990 - pres. 
Research Fellow, McGill University, Meakins-Christie Lab, Montreal, Canada 
Assistant Professor of Medicine, University of North Carolina, Chapel Hill, NC 
Associate Professor of Medicine, University of North Carolina, Chapel Hill, NC 
Professor of Medicine, University of North- Carolina, Chapel Hill, NC 
Director, UNC Cystic Fibrosis Center, Chapel Hill, NC 
Director, Pulmonary Division University of North Carolina, Chapel Hill, NC 
Professional Societies: 
American Society for Clinical Investigation 
American Thoracic Society 
Association of American College of Physicians 
Honors: 
Phi Beta Kappa 
Alpha Omega Alpha 
American Heart Established Investigator, 1980-1984 
Doris Tulcin Cystic Fibrosis Research Award, 1989 
Memberships: 
1990-pres. National Institute of Health - HLBI Research Review Committee A 
Publications (23 out of 160): 
1. Knowles, M.R., J.L. Carson, A.M. Collier, J.T. Gatzy and R.C. Boucher. Measurements of nasal 
transepithelial electric potential differences in normal human subjects in vivo. Am. Rev. Respir. Dis. 
124:484-490, 1981. 
2. Knowles, M.R., J.T. Gatzy and R.C. Boucher. Increased bioelectric potential difference across 
respiratory epithelia in cystic fibrosis. N. Engl. J. Med. 305:1489-1495, 1981. 
3. Knowles, M., J. Gatzy and R. Boucher. Relative ion permeability of normal and cystic fibrosis nasal 
epithelium. J. Clin. Invest. 71:1410-1417, 1983. 
4. Knowles, M.R., M.J. Stutts, A. Spock, N. Fischer, J.T. Gatzy and R.C ^Boucher. Abnormal ion 
permeation through cystic fibrosis respiratory epithelium. Science 221.1067-1070, 983. 
5. Boucher, R.C., M.J. Stutts, M.R. Knowles, L. Cantley and J.T. Gatzy. Na + transport in cystic 
fibrosis respiratory epithelia: Abnormal basal rate and response to adenylate cyclase activation. /. 
Clin. Invest. 78:1245-1252, 1986. 
nM a Rpcp.arch. Volume 17 
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